Mannose 6-dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T.
Mol Cell Biol 2011 Dec 12. [Epub ahead of print]...Abstract

Dysregulation of Rho GTPases in the {alpha}Pix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
Ramakers GJ, Wolfer D, Rosenberger G, Kuchenbecker K, Kreienkamp HJ, Prange-Kiel J, Rune G, Richter K, Langnaese K, Masneuf S, Bösl MR, Fischer KD, Krugers HJ, Lipp HP, van Galen E, Kutsche K.
Hum Mol Genet. 2011 Oct 18. [Epub ahead of print]...Abstract

The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis.
Kortüm F, Das S, Flindt M, Morris-Rosendahl DJ, Stefanova I, Goldstein A, Horn D, Klopocki E, Kluger G, Martin P, Rauch A, Roumer A, Saitta S, Walsh LE, Wieczorek D, Uyanik G, Kutsche K, Dobyns WB.
J Med Genet. 2011;48(6): 396-406....Abstract

Phenotypic spectrum associated with CASK loss-of-function mutations.
Moog U, Kutsche K, Kortüm F, Chilian B, Bierhals T, Apeshiotis N, Balg S, Chassaing N, Coubes C, Das S, Engels H, Van Esch H, Grasshoff U, Heise M, Isidor B, Jarvis J, Koehler U, Martin T, Oehl-Jaschkowitz B, Ortibus E, Pilz DT, Prabhakar P, Rappold G, Rau I, Rettenberger G, Schlüter G, Scott RH, Shoukier M, Wohlleber E, Zirn B, Dobyns WB, Uyanik G.
J Med Genet. 2011;48(11):741-51....Abstract

Altered endocannabinoid signalling after a high-fat diet in Apoe (-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.
Bartelt A, Orlando P, Mele C, Ligresti A, Toedter K, Scheja L, Heeren J, Di Marzo V.
Diabetologia. 2011; 54(11): 2900-10....Abstract

PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication.
Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett RD.
J Cell Sci. 2011; 124(Pt 2): 280-91. ...Abstract

Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo.
Prawitt J, Beil FT, Marshall RP, Bartelt A, Ruether W, Heeren J, Amling M, Staels B, Niemeier A.
Bone. 2011; 48(2): 339-46. ...Abstract

N-glycans and glycosylphosphatidylinositol-anchor act on polarized sorting of mouse PrP(C) in Madin-Darby canine kidney cells.
Puig B, Altmeppen HC, Thurm D, Geissen M, Conrad C, Braulke T, Glatzel M. PLoS One 2011; 6(9): e24624. ...Abstract

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo.
Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D, Jorissen E, Petrowitz B, Bartsch U, De Strooper B, Saftig P, Glatzel M.
Molecular Neurodegeneration 2011; 6:36...Abstract

A Mutation in the Golgi Qb-SNARE Gene GOSR2 Causes Progressive Myoclonus Epilepsy with Early Ataxia.
Corbett MA, Schwake M, Bahlo M, Dibbens LM, Lin M, Gandolfo LC, Vears DF, O'Sullivan JD, Robertson T, Bayly MA, Gardner AE, Vlaar AM, Korenke GC, Bloem BR, de Coo IF, Verhagen JM, Lehesjoki AE, Gecz J, Berkovic SF.
Am J Hum Genet.88:657-63...Abstract

Posttranslational modifications of the gamma-subunit affect intracellular trafficking and complex assembly of the GLcNac-1-phosphotransferase.
Encarnacao M, Kollmann K, Trusch M, Braulke T, Pohl S.
J Biol Chem 2011; 286: 5311-5318]...Abstract

Brown adipose tissue activity controls triglyceride clearance.
Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmüller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J.
Nat Med. 2011; 17, 200–205...Abstract

A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism.
Marschner K, Kollmann K, Schweizer M, Braulke T, Pohl S.
Science. 2011; 333: 87-90. ...Abstract

Regional and Subcellular Distribution of the Receptor-Targeting Protein PIST/GOPC in the Rat Central Nervous System
Chen A, Goessling E, Witkowski L, Bhindi A, Bauch C, Roussy G, Sarret P, Kreienkamp H-J, and Stroh T.
J Comp Neurol. 2011 Sep 22. doi: 10.1002/cne.22774. [Epub ahead of print] (The first two authors contributed equally)...Abstract

Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase
Kokkola T, Kruse C, Roy-Pogodzik E-M, Pekkinen J, Bauch C, Hönck H-H, Hennemann H, Kreienkamp H-J
Febs Lett., in press

2010

Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity.
Bartelt A, Beil FT, Schinke T, Roeser K, Ruether W, Heeren J, Niemeier A.
Bone. 2010 47:736-45....Abstract


Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand {beta}-glucocerebrosidase.
Blanz J, Groth J, Zachos C, Wehling C, Saftig P, Schwake M.
Hum Mol Genet. 2010; 19:563-572...Abstract


Loss of N-acetylglucosamine-1-phosphotransferase gamma subunit due to intronic mutation in GNPTG causes mucolipidosis type III gamma: Implications for molecular and cellular diagnostics.
Pohl S, Encarnacão M, Castrichini M, Müller-Loennies S, Muschol N, Braulke T.
Am J Med Genet A. 2010 Jan;152A(1):124-32. ...Abstract


Mannose phosphorylation in health and disease.
Kollmann K, Pohl S, Marschner K, Encarnação M, Sakwa I, Tiede S, Poorthuis BJ, Lübke T, Müller-Loennies S, Storch S, Braulke T.
Eur J Cell Biol. 2010;89:117-123....Abstract


Lysosomal targeting of the CLN7 membrane glycoprotein and transport via the plasma membrane require a dileucine motif.
Steenhuis P, Herder S, Gelis S, Braulke T, Storch S.
Traffic 2010; 11:987-1000 ....Abstract


Proteolytic processing of the {γ}-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages.
Pohl S, Tiede S, Marschner K, Encarnacao M, Castrichini M, Kollmann K, Muschol N, Ullrich K, Mueller-Loennies S, Braulke T.
J Biol Chem 2010; 285:23936-23944....Abstract


Yersinia virulence factor YopM induces sustained RSK activation by interfering with dephosphorylation.
Hentschke M, Berneking L, Belmar Campos C, Buck F, Ruckdeschel K. Aepfelbacher M.
PLoS One. 2010 Oct 5;5(10). pii: e13165. ...Abstract

2009

Glycosylation- and phosphorylation-dependent intracellular transport of lysosomal hydrolases
Sandra Pohl, Katrin Marschner, Stephan Storch, and Thomas Braulke<
Biol Chem. 2009 Jul;390(7):521-7. Review


Yersinia enterocolitica differentially modulates RhoG activity in host cells.
Roppenser B, Röder A, Hentschke M, Ruckdeschel K, Aepfelbacher M.
J Cell Sci. 2009 Mar 1;122(Pt 5):696-705. ....Abstract


Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
Paul Saftig and Judit Klumperman
Nat Rev Mol Cell Biol. 2009 Sep;10(9):623-35. Review.

Sequence requirements for the export of the Plasmodium falciparum Maurer's clefts protein REX2.
Haase S, Herrmann S, Grüring C, Heiber A, Jansen PW, Langer C, Treeck M, Cabrera A, Bruns C, Struck NS, Kono M, Engelberg K, Ruch U, Stunnenberg HG, Gilberger TW, Spielmann T.
Mol Microbiol. 2009 Feb;71(4):1003-17. ....Abstract